Early Hippocratic-era treatises begin circulatingJan 1, 450 BCELabels: Hippocratic Corpus, CnidusCorpusBMJ
Composition of *On Airs, Waters, Places*Jan 1, 430 BCELabels: Airs Waters, environmental medicineBritannicaCorpus
*On Ancient Medicine* argues for empirical practiceJan 1, 420 BCELabels: On Ancient, empirical practiceAncientMedCorpus
Clinical case-record style in *Epidemics* developsJan 1, 410 BCELabels: Epidemics, case recordsCorpusBMJ
*On the Nature of Man* formulates humoral balanceJan 1, 400 BCELabels: On the, humorismNatureManEulogikon
Hippocratic Oath tradition emerges within the CorpusJan 1, 380 BCELabels: Hippocratic Oath, medical ethicsOathBMJ
Earliest monumental phase of the Kos AsklepieionJan 1, 350 BCELabels: Kos Asklepieion, sanctuaryPubMedKosGR
Alexandrian-era gathering of Hippocratic writings beginsJan 1, 300 BCELabels: Alexandria, text collectionBMJPinakes
Hippocratic medicine becomes a classical reference traditionJan 1, 280 BCELabels: Hippocratic tradition, medical pedagogyBritannicaCorpus